Tyr397

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Home > Phosphorylation Site Page: > Tyr397 - CASP9 (human)

Site Information
AVSVkGIyKQMPGCF SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 286046008

In vivo Characterization
Methods used to characterize site in vivo:	[32P] ATP in vitro ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	E.coli (bacterial) ( 1 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Putative in vivo kinases:	Abl (human) ( 1 )
Kinases, in vitro:	Abl (human) ( 1 )

Downstream Regulation
Effects of modification on CASP9:	enzymatic activity, inhibited ( 1 )

References
1	Serrano BP, Szydlo HS, Alfandari D, Hardy JA (2017) Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9. J Biol Chem 292, 21352-21365 29066624 Curated Info

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