Ser20

Site Information
PADAIPKsKKVKVsH SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2850003

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 ) , mutation of modification site ( 2 )
Disease tissue studied:	breast cancer ( 1 )
Relevant cell line - cell type - tissue:	SKBr3 (breast cell) ( 1 ) , tsBN2 (fibroblast) ( 2 )

Downstream Regulation
Effects of modification on RCC1:	molecular association, regulation ( 2 )
Inhibit interaction with:	KPNA4 (human) ( 2 )

References
1	Imami K, et al. (2012) Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways. Mol Cell Proteomics 11, 1741-57 22964224 Curated Info
2	Horiike Y, Kobayashi H, Sekiguchi T (2009) Ran GTPase guanine nucleotide exchange factor RCC1 is phosphorylated on serine 11 by cdc2 kinase in vitro. Mol Biol Rep 36, 717-23 18568422 Curated Info