Tyr302
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Home > Phosphorylation Site Page: > Tyr302  -  RACK1 (human)

Site Information
GQTLFAGyTDNLVRV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2850000

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
MCF-7 (breast cell) ( 1 ) , MEF (fibroblast) ( 1 )

Downstream Regulation
Effects of modification on RACK1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, altered ( 1 ) , cell motility, altered ( 1 )
Induce interaction with:
ITGB1 (human) ( 1 ) , PPP2CA (human) ( 1 )

References 

1

Kiely PA, et al. (2008) Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration. J Biol Chem 283, 22952-61
18567578   Curated Info