Tyr44
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Home > Phosphorylation Site Page: > Tyr44  -  Tip60 (human)

Site Information
ISGRKLFyVHYIDFN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 28132103

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Abi-1 (human) ( 2 ) , HP1 alpha (human) ( 2 )
Kinases, in vitro:
Abl (human) ( 2 )
Treatments:
imatinib ( 2 ) , ionizing_radiation ( 2 ) , okadaic_acid ( 2 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on Tip60:
enzymatic activity, induced ( 2 ) , molecular association, regulation ( 1 , 2 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , DNA repair, induced ( 2 )
Induce interaction with:
AGO2 (human) ( 1 ) , DNA ( 2 ) , H3 (human) ( 2 )

References 

1

Wang Q, Goldstein M (2016) Small RNAs Recruit Chromatin-Modifying Enzymes MMSET and Tip60 to Reconfigure Damaged DNA upon Double-Strand Break and Facilitate Repair. Cancer Res 76, 1904-15
26822153   Curated Info

2

Kaidi A, Jackson SP (2013) KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 498, 70-4
23708966   Curated Info