Lys22
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Home > Sumoylation Site Page: > Lys22  -  IkB-alpha (human)

Site Information
GPRDGLkkERLLDDR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2798312

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
RWDD3 (human) ( 1 )

Downstream Regulation
Effects of modification on IkB-alpha:
protein stabilization ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Carbia-Nagashima A, et al. (2007) RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell 131, 309-23
17956732   Curated Info