Ser377
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser377  -  MOR-1 (human)

Site Information
QNtRDHPstANtVDR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447784

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 3 , 4 ) , phospho-antibody ( 1 , 2 , 3 , 4 ) , western blotting ( 1 , 2 , 3 , 4 )
Disease tissue studied:
breast cancer ( 4 ) , neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
NPFFR2 (human) ( 2 )
Putative in vivo kinases:
GRK2 (human) ( 2 )
Treatments:
1DMe ( 2 ) , AT-034 ( 1 ) , AT-121 ( 1 ) , AT-201 ( 1 ) , AT-324 ( 1 ) , cebranopadol ( 1 ) , clonidine ( 2 ) , DAMGO ( 2 , 3 ) , EGF ( 4 ) , etorphine ( 3 ) , fentanyl ( 3 ) , morphine ( 3 ) , naloxone ( 2 ) , PTX ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on MOR-1:
receptor desensitization, induced ( 2 ) , receptor internalization, altered ( 4 )
Effects of modification on biological processes:
signaling pathway regulation ( 3 )

References 

1

Dasgupta P, et al. (2022) Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics. Sci Rep 12, 7154
35504962   Curated Info

2

Moul├ędous L, et al. (2012) GRK2 protein-mediated transphosphorylation contributes to loss of function of ╬╝-opioid receptors induced by neuropeptide FF (NPFF2) receptors. J Biol Chem 287, 12736-49
22375000   Curated Info

3

Zheng H, et al. (2011) Modulating {micro}-Opioid Receptor Phosphorylation Switches Agonist-dependent Signaling as Reflected in PKC{epsilon} Activation and Dendritic Spine Stability. J Biol Chem 286, 12724-33
21292762   Curated Info

4

Chen Y, et al. (2008) EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation. Mol Biol Cell 19, 2973-83
18463167   Curated Info