Lys388
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Home > Sumoylation Site Page: > Lys388  -  AR (human)

Site Information
PHPHARIkLENPLDy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2793917

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 6 ) , immunoprecipitation ( 5 , 6 ) , mutation of modification site ( 2 , 4 , 5 , 6 ) , western blotting ( 5 , 6 )
Disease tissue studied:
bone cancer ( 5 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
RAI17 (human) ( 4 )

Downstream Regulation
Effects of modification on AR:
molecular association, regulation ( 4 , 6 ) , protein processing ( 2 )
Effects of modification on biological processes:
transcription, induced ( 4 ) , transcription, inhibited ( 5 , 6 )
Induce interaction with:
DNA ( 6 ) , RAI17 (human) ( 4 )

References 

1

Lumpkin RJ, et al. (2017) Site-specific identification and quantitation of endogenous SUMO modifications under native conditions. Nat Commun 8, 1171
29079793   Curated Info

2

Mukherjee S, et al. (2009) Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation. J Biol Chem 284, 21296-306
19497852   Curated Info

3

Callewaert L, Verrijdt G, Haelens A, Claessens F (2004) Differential effect of small ubiquitin-like modifier (SUMO)-ylation of the androgen receptor in the control of cooperativity on selective versus canonical response elements. Mol Endocrinol 18, 1438-49
15031320   Curated Info

4

Sharma M, et al. (2003) hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci. EMBO J 22, 6101-14
14609956   Curated Info

5

Nishida T, Yasuda H (2002) PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. J Biol Chem 277, 41311-7
12177000   Curated Info

6

Poukka H, Karvonen U, Janne OA, Palvimo JJ (2000) Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1). Proc Natl Acad Sci U S A 97, 14145-50
11121022   Curated Info