Tyr164
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Home > Phosphorylation Site Page: > Tyr164  -  SPTLC1 (human)

Site Information
KTEEAIIySYGFATI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27930808

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , chronic myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
K562 (erythroid) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 1 )
Kinases, in vitro:
Abl (human) ( 1 )

Downstream Regulation
Effects of modification on SPTLC1:
enzymatic activity, inhibited ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 )

References 

1

Taouji S, et al. (2013) Phosphorylation of serine palmitoyltransferase long chain-1 (SPTLC1) on tyrosine 164 inhibits its activity and promotes cell survival. J Biol Chem 288, 17190-201
23629659   Curated Info