Lys164
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Home > Acetylation Site Page: > Lys164  -  p53 (human)

Site Information
VRAMAIYkQSQHMTE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2793003

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 6 ) , mutation of modification site ( 5 , 6 ) , phospho-antibody ( 6 )
Disease tissue studied:
colorectal cancer ( 6 ) , colorectal carcinoma ( 6 ) , lung cancer ( 5 , 6 ) , non-small cell lung cancer ( 5 , 6 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
etoposide ( 6 ) , nicotinamide ( 6 ) , trichostatin_A ( 6 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 6 ) , transcription, altered ( 5 , 6 )

References 

1

Leszczynska KB, et al. (2015) Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT. J Clin Invest 125, 2385-98
25961455   Curated Info

2

Zhang ZN, Chung SK, Xu Z, Xu Y (2014) Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells 32, 157-65
24038750   Curated Info

3

Chang J, et al. (2013) Acetylation of p53 stimulates miRNA processing and determines cell survival following genotoxic stress. EMBO J 32, 3192-205
24219989   Curated Info

4

Wu SY, Chiang CM (2009) Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding. EMBO J 28, 1246-59
19339993   Curated Info

5

Tian C, et al. (2009) KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis. Nat Cell Biol 11, 580-91
19377469   Curated Info

6

Tang Y, et al. (2008) Acetylation is indispensable for p53 activation. Cell 133, 612-26
18485870   Curated Info