Ser421
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Home > Phosphorylation Site Page: > Ser421  -  JIP1 (human)

Site Information
DNCASVSsPYESAIG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458259

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoassay ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , phosphopeptide mapping ( 3 )
Relevant cell line - cell type - tissue:
'neuron, dorsal root ganglion'-brain ( 1 ) , 293 (epithelial) ( 2 ) , COS (fibroblast) ( 3 ) , HN33 (neuron) ( 3 )

Upstream Regulation
Putative upstream phosphatases:
DUSP1 (human) ( 1 )
Treatments:
anisomycin ( 2 )

Downstream Regulation
Effects of modification on JIP1:
protein conformation ( 1 )

References 

1

Fu MM, Nirschl JJ, Holzbaur EL (2014) LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes. Dev Cell 29, 577-90
24914561   Curated Info

2

D'Ambrosio C, et al. (2006) Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease. Mol Cell Proteomics 5, 97-113
16195223   Curated Info

3

Nihalani D, Wong HN, Holzman LB (2003) Recruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation. J Biol Chem 278, 28694-702
12756254   Curated Info