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Site Information |
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PGWEkRMsRSSGRVy SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 447772 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Downstream Regulation | |
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Effects of modification on PIN1: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
Disease / Diagnostics Relevance | |
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Relevant diseases: |
References | |
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Xu D, et al. (2016) Obg-like ATPase 1 regulates global protein serine/threonine phosphorylation in cancer cells by suppressing the GSK3β-inhibitor 2-PP1 positive feedback loop. Oncotarget 7, 3427-39
26655089 Curated Info |
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Han HJ, et al. (2016) Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α. PLoS One 11, e0147038
26784107 Curated Info |
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Lee YC, et al. (2013) Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex. J Cell Sci 126, 4862-72
23970419 Curated Info |
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Ando K, et al. (2013) Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker. Neurobiol Aging 34, 757-69
22926167 Curated Info |
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Nechama M, Lin CL, Richter JD (2013) An unusual two-step control of CPEB destruction by Pin1. Mol Cell Biol 33, 48-58
23090969 Curated Info |
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Khanal P, et al. (2012) Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells. Oncogene 31, 3845-56
22158035 Curated Info |
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Sami F, et al. (2011) Molecular Basis for an Ancient Partnership between Prolyl Isomerase Pin1 and Phosphatase Inhibitor-2. Biochemistry 50, 6567-78
21714498 Curated Info |
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Li M, Stukenberg PT, Brautigan DL (2008) Binding of phosphatase inhibitor-2 to prolyl isomerase Pin1 modifies specificity for mitotic phosphoproteins. Biochemistry 47, 292-300
18062707 Curated Info |
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Lu PJ, et al. (2002) Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. J Biol Chem 277, 2381-4
11723108 Curated Info |
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Lu PJ, Zhou XZ, Shen M, Lu KP (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325-8
10037602 Curated Info |