Ser554
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser554  -  CENTB1 (human)

Site Information
sIRPRPGsLRSkPEP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458238

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 2 , 3 , 4 , 5 ) , mutation of modification site ( 1 , 5 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 )
Relevant cell line - cell type - tissue:
breast ( 2 ) , HeLa (cervical) ( 1 , 5 ) , Jurkat (T lymphocyte) ( 3 , 4 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 , 5 )
Kinases, in vitro:
Akt1 (human) ( 5 )
Treatments:
siRNA ( 1 )

Downstream Regulation
Effects of modification on CENTB1:
molecular association, regulation ( 5 )
Effects of modification on biological processes:
cell motility, altered ( 5 )
Induce interaction with:
ITGB1 (human) ( 5 )

References 

1

Hsu JW, et al. (2020) The protein kinase Akt acts as a coat adaptor in endocytic recycling. Nat Cell Biol
32541877   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mulhern D (2012) CST Curation Set: 13828; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R)
Curated Info

4

Guo A (2011) CST Curation Set: 12059; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pTXR
Curated Info

5

Li J, et al. (2005) Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration. Dev Cell 9, 663-73
16256741   Curated Info