Ser508
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Home > Phosphorylation Site Page: > Ser508  -  TBX21 (mouse)

Site Information
PsSGDSSsPAGAPsP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458229

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
AE7 ( 2 ) , HEK293T (epithelial) ( 2 ) , T lymphocyte-spleen ( 1 )

Upstream Regulation
Kinases, in vitro:
CK1A (human) ( 2 ) , GSK3A (human) ( 2 )
Treatments:
rapamycin ( 1 )

Downstream Regulation
Effects of modification on TBX21:
molecular association, regulation ( 2 )
Induce interaction with:
NFkB-p65 (human) ( 2 )

References 

1

Chornoguz O, et al. (2017) mTORC1 Promotes T-bet Phosphorylation To Regulate Th1 Differentiation. J Immunol 198, 3939-3948
28424242   Curated Info

2

Hwang ES, Hong JH, Glimcher LH (2005) IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med 202, 1289-300
16275766   Curated Info