Ser243
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser243  -  GLI1 (human)

Site Information
DCRWDGCsQEFDSQE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27708601

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
brain cancer ( 1 ) , medulloblastoma ( 1 ) , BCC ( 2 )
Relevant cell line - cell type - tissue:
293T (epithelial) ( 1 ) , 3T3 (fibroblast) ( 1 ) , Daoy ( 1 ) , epidermal ( 2 )

Upstream Regulation
Putative in vivo kinases:
MEKK3 (human) ( 1 ) , PKCI (human) ( 2 )

Downstream Regulation
Effects of modification on GLI1:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, induced ( 2 ) , transcription, induced ( 2 ) , transcription, inhibited ( 1 )
Induce interaction with:
DNA ( 2 ) , SUFU (human) ( 1 )
Inhibit interaction with:
DNA ( 1 )

References 

1

Lu J, et al. (2018) MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function. Oncogene
29662197   Curated Info

2

Atwood SX, et al. (2013) GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas. Nature 494, 484-8
23446420   Curated Info