Tyr1325
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Home > Phosphorylation Site Page: > Tyr1325  -  NMDAR2A (human)

Site Information
RLLEGNFyGSLFSVP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458211

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
HIV Encephalitis ( 1 )
Relevant cell line - cell type - tissue:
293T (epithelial) ( 2 ) , brain ( 1 ) , neuron ( 1 )

Upstream Regulation
Putative in vivo kinases:
Src (human) ( 2 )
Kinases, in vitro:
Fyn (human) ( 2 ) , Src (human) ( 1 )
Treatments:
SrcI ( 1 ) , Tat ( 1 )

Downstream Regulation
Effects of modification on NMDAR2A:
activity, induced ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
HIV Encephalitis ( 1 )

References 

1

King JE, et al. (2010) Mechanisms of HIV-tat-induced phosphorylation of N-methyl-D-aspartate receptor subunit 2A in human primary neurons: implications for neuroAIDS pathogenesis. Am J Pathol 176, 2819-30
20448061   Curated Info

2

Taniguchi S, et al. (2009) Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour. EMBO J 28, 3717-29
19834457   Curated Info