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Site Information |
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EDDyPNGyLVVLPDS SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 447760 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Regulatory protein: | |
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Downstream Regulation | |
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Effects of modification on LAT: | |
Effects of modification on biological processes: | |
Induce interaction with: |
References | |
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Lo WL, et al. (2023) A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat Immunol 24, 676-689
36914891 Curated Info |
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Nguyen TTT, et al. (2021) Cbl-b deficiency prevents functional but not phenotypic T cell anergy. J Exp Med 218
33974042 Curated Info |
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Cui Y, et al. (2019) A novel model for treatment of hypertrophic pachymeningitis. Ann Clin Transl Neurol 6, 431-444
30911567 Curated Info |
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Driessens G, et al. (2011) Beta-catenin inhibits T cell activation by selective interference with linker for activation of T cells-phospholipase C-γ1 phosphorylation. J Immunol 186, 784-90
21149602 Curated Info |
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Chuck MI, Zhu M, Shen S, Zhang W (2010) The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. J Immunol 184, 2476-86
20130215 Curated Info |
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Ragab A, et al. (2007) Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation. Blood 110, 2466-74
17579183 Curated Info |
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Zhu M, et al. (2006) Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB. Immunity 25, 757-68
17081783 Curated Info |
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Malbec O, et al. (2004) Linker for activation of T cells integrates positive and negative signaling in mast cells. J Immunol 173, 5086-94
15470052 Curated Info |
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Sommers CL, et al. (2002) A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296, 2040-3
12065840 Curated Info |
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Aguado E, et al. (2002) Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296, 2036-40
12065839 Curated Info |
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Sommers CL, et al. (2001) Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development. J Exp Med 194, 135-42
11457888 Curated Info |