Ser447

Site Information
ARVsPPEsPRARAPA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2761601

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 5 , 6 , 8 ) , phospho-antibody ( 7 )
Relevant cell line - cell type - tissue:	'brain, cerebral cortex' ( 6 ) , 'brain, forebrain' ( 8 ) , brain ( 2 , 3 , 4 , 5 ) , neuron:synaptosome-brain ( 7 )

Upstream Regulation
Treatments:	BDNF ( 7 ) , okadaic_acid ( 7 )

References
1	Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250 27841257 Curated Info
2	Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29 22645316 Curated Info
3	Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9 22807455 Curated Info
4	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
5	Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9 20415495 Curated Info
6	Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82 19737024 Curated Info
7	Simsek-Duran F, Lonart G (2008) The role of RIM1alpha in BDNF-enhanced glutamate release. Neuropharmacology 55, 27-34 18499195 Curated Info
8	Collins MO, et al. (2008) Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder. Mol Cell Proteomics 7, 1331-48 18388127 Curated Info