Ser18
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Home > Phosphorylation Site Page: > Ser18  -  p53 iso2 (mouse)

Site Information
ISLELPLsQETFSGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447490

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
DLD1 (intestinal) ( 1 ) , HCT116 (intestinal) ( 1 ) , MEF (fibroblast) ( 2 ) , thymus [genetic knockin] ( 3 )

Upstream Regulation
Regulatory protein:
EXO1 (mouse) ( 2 )
Kinases, in vitro:
ATR (human) ( 2 )
Treatments:
UV ( 2 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, altered ( 3 ) , cell motility, altered ( 3 )

References 

1

Li N, et al. (2015) FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. Oncotarget 6, 9240-56
25860929   Curated Info

2

Lindsey-Boltz LA, et al. (2014) Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. J Biol Chem 289, 5074-82
24403078   Curated Info

3

Armata HL, et al. (2011) Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis. PLoS One 6, e24813
21980358   Curated Info