Thr8
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Home > Phosphorylation Site Page: > Thr8  -  p16-INK4A iso5 (human)

Site Information
MVRRFLVtLRIRRAC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27523604

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
bone cancer ( 1 , 3 ) , lung cancer ( 1 , 3 ) , non-small cell lung cancer ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 3 )

Downstream Regulation
Effects of modification on p16-INK4A iso5:
intracellular localization ( 1 , 2 , 3 ) , protein stabilization ( 2 , 3 )
Effects of modification on biological processes:
cell adhesion, altered ( 1 ) , cell growth, induced ( 1 , 3 )

References 

1

Fontana R, et al. (2018) PKC Dependent p14ARF Phosphorylation on Threonine 8 Drives Cell Proliferation. Sci Rep 8, 7056
29728595   Curated Info

2

Vivo M, et al. (2015) MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells. PLoS One 10, e0117252
25723571   Curated Info

3

Vivo M, et al. (2013) Mimicking p14ARF phosphorylation influences its ability to restrain cell proliferation. PLoS One 8, e53631
23308265   Curated Info