Lys281

Site Information
LSGEMAVkREQLKNG GenPept Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 27490404

In vivo Characterization
Methods used to characterize site in vivo:	electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:	liver cancer ( 1 )
Relevant cell line - cell type - tissue:	HepG2 (hepatic) ( 1 )

Downstream Regulation
Effects of modification on TR-alpha:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	transcription, altered ( 1 )
Induce interaction with:	N-CoR1 (human) ( 1 ) , Src (human) ( 1 )
Inhibit interaction with:	DNA ( 1 )

References
1	Weitzel JM (2016) Impaired Repressor Function in SUMOylation-Defective Thyroid Hormone Receptor Isoforms. Eur Thyroid J 5, 152-163 27843805 Curated Info