Lys389
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Home > Sumoylation Site Page: > Lys389  -  TR-alpha iso2 (rat)

Site Information
ASRFLHMkVECPTEL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27490405

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:
adipose tissue ( 1 ) , C2C12 (myoblast) ( 1 ) , GH3 (epithelial) ( 1 ) , heart ( 1 ) , HepG2 (hepatic) ( 1 ) , liver ( 1 )

Upstream Regulation
Regulatory protein:
PIAS1 (human) ( 1 ) , PIAS3 (human) ( 1 ) , PIAS4 (human) ( 1 )
Treatments:
liothyronine ( 1 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 1 )

References 

1

Liu YY, et al. (2012) Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation. J Biol Chem 287, 36499-508
22930759   Curated Info

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