Ser106
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Home > Phosphorylation Site Page: > Ser106  -  p53 (human)

Site Information
sQkTYQGsYGFrLGF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27300200

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurA (human) ( 1 )
Kinases, in vitro:
AurA (human) ( 1 )

Downstream Regulation
Effects of modification on p53:
protein stabilization ( 1 )
Inhibit interaction with:
MDM2 (human) ( 1 )

References 

1

Hsueh KW, et al. (2013) A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2. Biochim Biophys Acta 1834, 508-515
23201157   Curated Info