Ser571
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Home > Phosphorylation Site Page: > Ser571  -  SCN5A (mouse)

Site Information
PWPLRRPsTQGQPGF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27281507

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 6 ) , immunoprecipitation ( 1 , 8 ) , mass spectrometry ( 1 , 4 , 8 ) , mutation of modification site ( 2 , 3 , 5 ) , phospho-antibody ( 2 , 3 , 6 , 7 ) , western blotting ( 2 , 3 , 4 , 6 , 7 )
Relevant cell line - cell type - tissue:
'heart, artery' ( 2 ) , 'heart, ventricle' ( 1 ) , heart ( 3 , 8 ) , HEK293-A (epithelial) ( 6 ) , myocardium ( 7 ) , myocyte ( 6 ) , myocyte-heart ( 2 , 5 )

Upstream Regulation
Putative in vivo kinases:
CAMK2A (human) ( 2 , 6 )
Treatments:
ischemia ( 3 ) , ischemia/reperfusion ( 3 ) , isoproterenol ( 6 ) , pressure ( 7 ) , taxol ( 6 )

Downstream Regulation
Effects of modification on SCN5A:
activity, induced ( 2 , 5 , 6 ) , enzymatic activity, induced ( 2 )

References 

1

Lorenzini M, et al. (2021) Proteomic and functional mapping of cardiac NaV1.5 channel phosphorylation sites. J Gen Physiol 153
33410863   Curated Info

2

Greer-Short A, et al. (2019) Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm
31622781   Curated Info

3

Howard T, et al. (2018) CaMKII-dependent late sodium current increases electrical dispersion and arrhythmia in ischemia/reperfusion. Am J Physiol Heart Circ Physiol
29932771   Curated Info

4

Burel S, et al. (2017) C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation. J Biol Chem 292, 17431-17448
28882890   Curated Info

5

Glynn P, et al. (2015) Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo. Circulation 132, 567-77
26187182   Curated Info

6

Dybkova N, et al. (2014) Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa. Cardiovasc Res 103, 168-77
24812278   Curated Info

7

Toischer K, et al. (2013) Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease. J Mol Cell Cardiol 61, 111-22
23570977   Curated Info

8

Marionneau C, et al. (2012) Mass Spectrometry-Based Identification of Native Cardiac Nav1.5 Channel α Subunit Phosphorylation Sites. J Proteome Res 11, 5994-6007
23092124   Curated Info