Arg139

Site Information
sGGyGGsrDyyssrs SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 27277582
Available spectra: 1 CST

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 )
Disease tissue studied:	gastric cancer ( 10 ) , lung cancer ( 5 , 6 , 7 ) , non-small cell lung cancer ( 7 , 8 , 9 , 11 , 12 ) , non-small cell lung adenocarcinoma ( 7 ) , non-small cell squamous cell lung carcinoma ( 12 ) , small-cell lung cancer ( 5 , 6 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , A549 (pulmonary) ( 9 ) , Calu-3 (pulmonary) ( 7 ) , DMS53 (pulmonary) ( 6 ) , DMS79 (pulmonary) ( 5 ) , HCC827 (pulmonary) ( 7 ) , HCT116 (intestinal) ( 4 , 13 ) , HEK293T (epithelial) [PADI4 (human), no information, doxycyline inducible over-expression of PADI4] ( 3 ) , Jurkat (T lymphocyte) ( 2 ) , lung ( 5 , 6 , 7 ) , MKN-45 (gastric) ( 10 ) , NCI-H128 (pulmonary) ( 5 ) , NCI-H1417 (pulmonary) ( 5 ) , NCI-H1650 (pulmonary) ( 7 ) , NCI-H1703 (squamous) ( 12 ) , NCI-H1975 (pulmonary) ( 7 ) , NCI-H209 (pulmonary) ( 5 ) , NCI-H2106 (pulmonary) ( 7 ) , NCI-H3122 (pulmonary) ( 8 ) , NCI-H3255 (pulmonary) ( 11 ) , NCI-H446 (pulmonary) ( 6 ) , NCI-H524 (pulmonary) ( 5 ) , NCI-H526 (pulmonary) ( 6 ) , NCI-H69 (pulmonary) ( 6 ) , NCI-H82 (pulmonary) ( 6 ) , T lymphocyte ( 2 )

References
1	Larsen SC, et al. (2016) Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells. Sci Signal 9, rs9 27577262 Curated Info
2	Geoghegan V, et al. (2015) Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling. Nat Commun 6, 6758 25849564 Curated Info
3	Sylvestersen KB, et al. (2014) Proteomic analysis of arginine methylation sites in human cells reveals dynamic regulation during transcriptional arrest. Mol Cell Proteomics 13, 2072-88 24563534 Curated Info
4	Guo A, et al. (2014) Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics 13, 372-87 24129315 Curated Info
5	Rikova K (2013) CST Curation Set: 20094; Year: 2013; Biosample/Treatment: cell line, H1417, DMS79, H128, H209, H524; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine [mme-R] MultiMab(TM) Rabbit mAb mix Cat#: 8015 Curated Info
6	Rikova K (2013) CST Curation Set: 20095; Year: 2013; Biosample/Treatment: cell line, DMS53, H526, H69, H82, H446; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine [mme-R] MultiMab(TM) Rabbit mAb mix Cat#: 8015 Curated Info
7	Rikova K (2013) CST Curation Set: 20098; Year: 2013; Biosample/Treatment: cell line, H1650, HCC827, H1975, Calu-3, H2106; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine [mme-R] MultiMab(TM) Rabbit mAb mix Cat#: 8015 Curated Info
8	Rikova K (2013) CST Curation Set: 18851; Year: 2013; Biosample/Treatment: cell line, H3122/crizotinib, geldanamycin; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine [mme-R] MultiMab(TM) Rabbit mAb mix Cat#: 8015 Curated Info
9	Rikova K (2012) CST Curation Set: 16037; Year: 2012; Biosample/Treatment: cell line, A549/iressa, gleevec, crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine (Me-R4-100) Rabbit mAb Cat#: 8015 Curated Info
10	Rikova K (2012) CST Curation Set: 16034; Year: 2012; Biosample/Treatment: cell line, MKN45/crizotinib; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine [mme-R] MultiMab(TM) Rabbit mAb mix Cat#: 8015 Curated Info
11	Rikova K (2012) CST Curation Set: 16035; Year: 2012; Biosample/Treatment: cell line, H3255/iressa; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine [mme-R] MultiMab(TM) Rabbit mAb mix Cat#: 8015 Curated Info
12	Rikova K (2012) CST Curation Set: 16036; Year: 2012; Biosample/Treatment: cell line, H1703/gleevec; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine [mme-R] MultiMab(TM) Rabbit mAb mix Cat#: 8015 Curated Info
13	Mulhern D (2011) CST Curation Set: 13240; Year: 2011; Biosample/Treatment: cell line, HCT116/untreated; Disease: colorectal carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m1R Antibodies Used to Purify Peptides prior to LCMS: Mono-Methyl Arginine (Me-R(4)-100) Rabbit mAb Cat#: 8015, PTMScan?(R) Mono-methyl arginine (r) Immunoaffinity Beads Cat#: 8163 Curated Info