Ser66
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Home > Phosphorylation Site Page: > Ser66  -  p63 iso2 (human)

Site Information
SSTFDALsPsPAIPS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451600

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , epithelial ( 3 ) , HEK293T (epithelial) ( 2 ) , keratinocyte ( 1 ) , keratinocyte-skin ( 2 ) , squamous ( 2 )

Upstream Regulation
Regulatory protein:
ERK2 (human) ( 1 ) , SMG1 (human) ( 1 )
Putative in vivo kinases:
CDK12 (human) ( 1 ) , P38A (human) ( 2 ) , TGFBR1 (human) ( 3 )
Kinases, in vitro:
P38A (human) ( 2 ) , TGFBR1 (human) ( 3 )
Treatments:
MG132 ( 3 ) , TGF-beta ( 3 ) , UV ( 1 , 3 )

Downstream Regulation
Effects of modification on p63 iso2:
protein degradation ( 2 , 3 )
Effects of modification on biological processes:
cell growth, inhibited ( 3 )

References 

1

Bamberger C, Pankow S, Yates JR (2021) SMG1 and CDK12 Link ΔNp63α Phosphorylation to RNA Surveillance in Keratinocytes. J Proteome Res 20, 5347-5358
34761935   Curated Info

2

Choo MK, Kraft S, Missero C, Park JM (2018) The protein kinase p38α destabilizes p63 to limit epidermal stem cell frequency and tumorigenic potential. Sci Signal 11
30301786   Curated Info

3

Cherukuri P, et al. (2012) Phosphorylation of ΔNp63α via a novel TGFβ/ALK5 signaling mechanism mediates the anti-clonogenic effects of TGFβ. PLoS One 7, e50066
23166821   Curated Info

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