Ser60
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Home > Phosphorylation Site Page: > Ser60  -  COPS6 (human)

Site Information
DHWIRMRsQEGRPVQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27166600

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 3 )
Disease tissue studied:
bone cancer ( 3 ) , breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
EGF (human) ( 1 )
Putative in vivo kinases:
Akt1 (human) ( 3 )
Kinases, in vitro:
Akt1 (human) ( 3 )
Treatments:
LY294002 ( 1 )

Downstream Regulation
Effects of modification on COPS6:
protein stabilization ( 1 , 2 , 3 ) , ubiquitination ( 3 )
Effects of modification on biological processes:
cell growth, induced ( 3 )

References 

1

Gao S, et al. (2015) COP9 signalosome subunit 6 (CSN6) regulates E6AP/UBE3A in cervical cancer. Oncotarget 6, 28026-41
26318036   Curated Info

2

Zhao R, et al. (2013) CDK inhibitor p57 (Kip2) is downregulated by Akt during HER2-mediated tumorigenicity. Cell Cycle 12, 935-43
23421998   Curated Info

3

Xue Y, et al. (2012) HER2-Akt signaling in regulating COP9 signalsome subunit 6 and p53. Cell Cycle 11, 4181-90
23095642   Curated Info