Tyr316
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Home > Phosphorylation Site Page: > Tyr316  -  TAZ (mouse)

Site Information
sGLGLGCySVPTTPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27138200

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HCT116 (intestinal) ( 1 ) , HEK293T (epithelial) ( 2 ) , MEF (fibroblast) [TAZ (mouse), homozygous knockout] ( 2 ) , SW480 (intestinal) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Abl (human) ( 2 )
Kinases, in vitro:
Abl (human) ( 2 ) , Src (human) ( 1 )
Treatments:
osmotic_stress ( 2 )

Downstream Regulation
Effects of modification on TAZ:
intracellular localization ( 1 ) , molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , transcription, induced ( 1 ) , transcription, inhibited ( 2 )
Induce interaction with:
TAZ (mouse) ( 2 )

References 

1

Byun MR, et al. (2017) SRC activates TAZ for intestinal tumorigenesis and regeneration. Cancer Lett 410, 32-40
28939028   Curated Info

2

Jang EJ, et al. (2012) TAZ Suppresses NFAT5 Activity through Tyrosine Phosphorylation. Mol Cell Biol 32, 4925-32
23045390   Curated Info