Ser166
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser166  -  RIPK1 (human)

Site Information
LAsFkMWskLNNEEH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 27116401

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 ) , mass spectrometry (in vitro) ( 5 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
breast cancer ( 4 ) , breast ductal carcinoma ( 4 ) , colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , lymphoma ( 2 ) , fibrosarcoma of soft tissue ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
RIPK1 (human) ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
multiple sclerosis ( 3 )

References 

1

Wu W, et al. (2020) The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death. Cell Rep 31, 107547
32320653   Curated Info

2

Moerke C, et al. (2018) The anticonvulsive Phenhydan suppresses extrinsic cell death. Cell Death Differ
30442947   Curated Info

3

Ofengeim D, et al. (2015) Activation of necroptosis in multiple sclerosis. Cell Rep 10, 1836-49
25801023   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Degterev A, et al. (2008) Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol 4, 313-21
18408713   Curated Info