Thr236
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Home > Phosphorylation Site Page: > Thr236  -  EDG-1 (human)

Site Information
RTRSRRLtFRKNISK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447691

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
CHO (fibroblast) [EphB1 (human), transfection] ( 2 ) , HUVEC (endothelial) ( 2 ) , muscle ( 2 )

Upstream Regulation
Regulatory protein:
Akt1 (human) ( 2 )
Putative in vivo kinases:
Akt1 (human) ( 2 )
Kinases, in vitro:
Akt1 (human) ( 2 )
Treatments:
IGF-1 ( 2 ) , LY294002 ( 2 ) , sphingosine_1-phosphate ( 2 ) , wortmannin ( 2 )

Downstream Regulation
Effects of modification on biological processes:
cell motility, altered ( 2 ) , cytoskeletal reorganization ( 2 )

References 

1

Chavez A, et al. (2015) S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness. J Cell Sci 128, 878-87
25588843   Curated Info

2

Lee MJ, et al. (2001) Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol Cell 8, 693-704
11583630   Curated Info