Thr72
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Home > Phosphorylation Site Page: > Thr72  -  Ets-2 (human)

Site Information
NCELPLLtPCSKAVM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447688

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mutation of modification site ( 1 , 2 , 3 , 4 , 5 ) , phospho-antibody ( 3 ) , phosphoamino acid analysis ( 5 ) , western blotting ( 3 )
Disease tissue studied:
leukemia ( 1 ) , T cell leukemia ( 1 ) , pancreatic cancer ( 2 ) , pancreatic carcinoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
HRas (human) ( 5 )
Treatments:
M-CSF ( 3 )

Downstream Regulation
Effects of modification on Ets-2:
activity, induced ( 5 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , cell cycle regulation ( 1 ) , cell differentiation, induced ( 1 ) , transcription, altered ( 3 , 4 ) , transcription, induced ( 1 , 2 )

References 

1

Fisher IB, Ostrowski M, Muthusamy N (2012) Role for Ets-2(Thr-72) transcription factor in stage-specific thymocyte development and survival. J Biol Chem 287, 5199-210
22128184   Curated Info

2

Zhang JS, et al. (2011) Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer. Oncogene 30, 3705-15
21441955   Curated Info

3

Ezashi T, Roberts RM (2004) Regulation of interferon-tau (IFN-tau) gene promoters by growth factors that target the Ets-2 composite enhancer: a possible model for maternal control of IFN-tau production by the conceptus during early pregnancy. Endocrinology 145, 4452-60
15217985   Curated Info

4

Lindemann RK, et al. (2003) Ets2 and protein kinase C epsilon are important regulators of parathyroid hormone-related protein expression in MCF-7 breast cancer cells. Biochem J 372, 787-97
12628005   Curated Info

5

Yang BS, et al. (1996) Ras-mediated phosphorylation of a conserved threonine residue enhances the transactivation activities of c-Ets1 and c-Ets2. Mol Cell Biol 16, 538-47
8552081   Curated Info