Ser392

Site Information
TAKtPKDsPGLPASA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 457601

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 )
Disease tissue studied:	neuroblastoma ( 4 )
Relevant cell line - cell type - tissue:	N1E-115 (neuron) ( 4 ) , PC-12 (chromaffin) [TrkA (rat), transfection] ( 3 ) , PC-12 (chromaffin) ( 3 ) , stromal ( 2 )

Upstream Regulation
Treatments:	LPA ( 4 )

References
1	Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250 27841257 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA (2012) The induction of serine/threonine protein phosphorylations by a PDGFR/TrkA chimera in stably transfected PC12 cells. Mol Cell Proteomics 11, 15-30 22027198 Curated Info
4	Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201 21454597 Curated Info