Ser372
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Home > Phosphorylation Site Page: > Ser372  -  RSK4 (human)

Site Information
TAkTPKDsPGLPAsA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457601

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 4 ) , peptide sequencing ( 5 ) , western blotting ( 5 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , lung cancer ( 4 ) , non-small cell lung cancer ( 4 ) , non-small cell lung adenocarcinoma ( 4 ) , non-small cell squamous cell lung carcinoma ( 4 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , CHO (fibroblast) ( 5 ) , COS (fibroblast) ( 5 ) , ES (stem) ( 5 ) , NCI-H1703 (squamous) ( 4 )

Upstream Regulation
Treatments:
EGF ( 5 ) , insulin ( 5 ) , U0126 ( 5 )

Downstream Regulation
Effects of modification on RSK4:
enzymatic activity, induced ( 5 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

3

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

4

Moritz A (2010) CST Curation Set: 9241; Year: 2010; Biosample/Treatment: cell line, NCI-H1703/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

5

D├╝mmler BA, et al. (2005) Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types. J Biol Chem 280, 13304-14
15632195   Curated Info