Thr1079
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Home > Phosphorylation Site Page: > Thr1079  -  LATS1 (human)

Site Information
EHAFyEFtFRRFFDD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 457595

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 9 ) , immunoprecipitation ( 5 , 6 , 8 ) , mass spectrometry ( 8 ) , mutation of modification site ( 5 , 8 , 9 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 8 , 9 ) , western blotting ( 2 , 3 , 4 , 5 , 6 , 8 , 9 )
Disease tissue studied:
breast cancer ( 4 , 9 ) , colorectal cancer ( 9 ) , colorectal carcinoma ( 9 ) , lung cancer ( 9 ) , non-small cell lung cancer ( 9 ) , non-small cell lung adenocarcinoma ( 9 ) , ovarian cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
LKB1 (human) ( 9 ) , MARK4 (human) ( 9 )
Kinases, in vitro:
MST2 (human) ( 5 , 11 )
Treatments:
2-deoxyglucose ( 7 , 8 ) , CNO ( 2 ) , doxycycline ( 9 ) , FGF2 ( 3 ) , miRNA ( 4 ) , virus infection ( 6 )

Downstream Regulation
Effects of modification on LATS1:
enzymatic activity, induced ( 11 )
Effects of modification on biological processes:
signaling pathway regulation ( 9 )

References 

1

Mei L, et al. (2017) SUMOylation of large tumor suppressor 1 at Lys751 attenuates its kinase activity and tumor-suppressor functions. Cancer Lett 386, 1-11
27847303   Curated Info

2

Yagi H, et al. (2016) GEP oncogene promotes cell proliferation through YAP activation in ovarian cancer. Oncogene 35, 4471-80
26804165   Curated Info

3

Hua G, et al. (2016) YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells. Oncogene 35, 2247-65
26364602   Curated Info

4

Nandy SB, et al. (2015) MicroRNA-125a influences breast cancer stem cells by targeting leukemia inhibitory factor receptor which regulates the Hippo signaling pathway. Oncotarget 6, 17366-78
25962054   Curated Info

5

Ni L, et al. (2015) Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling. Genes Dev 29, 1416-31
26108669   Curated Info

6

Liu G, et al. (2015) Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway. Oncogene 34, 3536-46
25195862   Curated Info

7

Wang W, et al. (2015) AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol 17, 490-9
25751139   Curated Info

8

Mo JS, et al. (2015) Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 17, 500-10
25751140   Curated Info

9

Mohseni M, et al. (2014) A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol 16, 108-17
24362629   Curated Info

10

Praskova M, Xia F, Avruch J (2008) MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol 18, 311-21
18328708   Curated Info

11

Chan EH, et al. (2005) The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 24, 2076-86
15688006   Curated Info