Ser268
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Home > Phosphorylation Site Page: > Ser268  -  CTNND1 iso3 (human)

Site Information
PQVRVGGssVDLHRF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450453

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HT-29 (intestinal) ( 1 ) , SW480 (intestinal) ( 1 )

Upstream Regulation
Regulatory protein:
CK1E (human) ( 1 ) , WNT3 (human) ( 1 )
Putative in vivo kinases:
CK1E (human) ( 1 )
Kinases, in vitro:
CK1A (human) ( 1 )
Treatments:
IC261 ( 1 )

Downstream Regulation
Effects of modification on CTNND1 iso3:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )
Induce interaction with:
Kaiso (human) ( 1 )
Inhibit interaction with:
CDH1 (human) ( 1 )

References 

1

Del Valle-Pérez B, et al. (2011) Wnt controls the transcriptional activity of Kaiso through CK1ε-dependent phosphorylation of p120-catenin. J Cell Sci 124, 2298-309
21670201   Curated Info

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