Ser58
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Home > Phosphorylation Site Page: > Ser58  -  p53 (mouse)

Site Information
EEFFEGPsEALRVSG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2624500

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
lung cancer ( 2 ) , non-small cell lung cancer ( 2 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 ) , testicular cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
HIPK2 (human) ( 2 )
Treatments:
UV ( 2 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, inhibited ( 2 ) , transcription, induced ( 1 )

References 

1

Cano CE, et al. (2009) Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function. Cancer Res 69, 219-26
19118006   Curated Info

2

Cecchinelli B, et al. (2006) Ser58 of mouse p53 is the homologue of human Ser46 and is phosphorylated by HIPK2 in apoptosis. Cell Death Differ 13, 1994-7
16729035   Curated Info