Ser3
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Home > Phosphorylation Site Page: > Ser3  -  CK2B (human)

Site Information
_____MsssEEVsWI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447647

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 9 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 ) , mutation of modification site ( 8 ) , phosphoamino acid analysis ( 9 ) , phosphopeptide mapping ( 9 )
Disease tissue studied:
cervical cancer ( 4 ) , cervical adenocarcinoma ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 9 ) , CK2A2 (human) ( 9 )

Downstream Regulation
Effects of modification on CK2B:
protein stabilization ( 8 )

References 

1

Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70
22496350   Curated Info

2

Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53
20363803   Curated Info

3

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

4

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

5

Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808
19651622   Curated Info

6

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

7

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info

8

Zhang C, Vilk G, Canton DA, Litchfield DW (2002) Phosphorylation regulates the stability of the regulatory CK2beta subunit. Oncogene 21, 3754-64
12032843   Curated Info

9

Litchfield DW, et al. (1991) Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2. J Biol Chem 266, 20380-9
1939094   Curated Info