Ser140

Site Information
GSPCSAPsPStPSFQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2591500

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 , 2 )
Disease tissue studied:	lung cancer ( 2 ) , non-small cell lung cancer ( 2 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 1 ) , NCI-H460 (pulmonary) ( 2 )

Downstream Regulation
Effects of modification on Nur77:	molecular association, regulation ( 1 )
Effects of modification on biological processes:	cell cycle regulation ( 1 )
Induce interaction with:	PIN1 (human) ( 1 )

References
1	Chen HZ, et al. (2012) Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis. Oncogene 31, 2876-87 22002310 Curated Info
2	Han YH, et al. (2006) Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt. Oncogene 25, 2974-86 16434970 Curated Info