Lys370
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Home > Mono-methylation Site Page: > Lys370  -  p53 (human)

Site Information
RAHsSHLkskkGQst   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2574935

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 2 )
Disease tissue studied:
bone cancer ( 2 ) , esophageal cancer ( 2 ) , esophageal carcinoma ( 2 ) , testicular cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
LLY-507 ( 2 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on p53:
activity, inhibited ( 1 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 1 ) , transcription, inhibited ( 1 )

References 

1

Zhu J, et al. (2016) Lysine methylation represses p53 activity in teratocarcinoma cancer cells. Proc Natl Acad Sci U S A 113, 9822-7
27535933   Curated Info

2

Nguyen H, et al. (2015) LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. J Biol Chem 290, 13641-53
25825497   Curated Info

3

Cui G, Botuyan MV, Mer G (2009) Preparation of recombinant peptides with site- and degree-specific lysine (13)C-methylation. Biochemistry 48, 3798-800
19334741   Curated Info

4

Huang J, et al. (2007) p53 is regulated by the lysine demethylase LSD1. Nature 449, 105-8
17805299   Curated Info

5

Huang J, et al. (2006) Repression of p53 activity by Smyd2-mediated methylation. Nature 444, 629-32
17108971   Curated Info