Ser151
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Home > Phosphorylation Site Page: > Ser151  -  FAM134B (human)

Site Information
AQLWRSLsESWEVIN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2509195

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , mass spectrometry ( 3 , 4 , 5 ) , mass spectrometry (in vitro) ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
bone cancer ( 2 ) , breast cancer ( 4 ) , breast ductal carcinoma ( 4 ) , HER2 positive breast cancer ( 3 ) , luminal A breast cancer ( 3 ) , luminal B breast cancer ( 3 ) , breast cancer, triple negative ( 3 , 4 ) , neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:
breast ( 3 , 4 ) , HEK293T (epithelial) ( 1 , 2 ) , Jurkat (T lymphocyte) ( 5 ) , neuron-dorsal root ganglia ( 2 ) , SKNSH (neural crest) ( 2 ) , U2OS (bone cell) ( 2 )

Upstream Regulation
Regulatory protein:
CBP (human) ( 1 )
Putative in vivo kinases:
CAMK2A (human) ( 1 ) , CAMK2B (human) ( 2 )
Kinases, in vitro:
CAMK2B (human) ( 2 )
Treatments:
C646 ( 1 ) , ionomycin ( 2 ) , ischemia ( 4 ) , KN-93 ( 2 ) , seocalcitol ( 2 ) , siRNA ( 1 , 2 )

Downstream Regulation
Effects of modification on FAM134B:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , autophagy, induced ( 1 )
Induce interaction with:
FAM134B (human) ( 2 )

References 

1

Wang X, et al. (2023) A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy. J Cell Biol 222
37043189   Curated Info

2

Jiang X, et al. (2020) FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. EMBO J, e102608
31930741   Curated Info

3

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

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