Thr205
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Home > Phosphorylation Site Page: > Thr205  -  FBXW7 (human)

Site Information
GLVPCSAtPTTFGDL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25585000

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 , 5 ) , mass spectrometry ( 4 ) , mutation of modification site ( 1 , 3 , 4 , 5 ) , phospho-antibody ( 4 ) , western blotting ( 3 )
Disease tissue studied:
colorectal cancer ( 5 ) , colorectal carcinoma ( 5 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 ) , pancreatic cancer ( 1 , 4 ) , pancreatic carcinoma ( 1 , 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 3 , 4 ) , ERK2 (human) ( 4 )
Kinases, in vitro:
ERK1 (human) ( 4 )
Treatments:
FTI277 ( 3 ) , MG132 ( 4 ) , SCH772984 ( 4 ) , selumetinib ( 4 ) , Trametinib ( 4 ) , U0126 ( 4 )

Downstream Regulation
Effects of modification on FBXW7:
molecular association, regulation ( 5 ) , protein degradation ( 1 , 3 , 4 , 5 ) , ubiquitination ( 3 , 4 , 5 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 , 4 , 5 ) , cell growth, induced ( 5 ) , transcription, induced ( 1 )
Induce interaction with:
PIN1 (human) ( 5 )

References 

1

Ye Z, et al. (2021) FBW7-NRA41-SCD1 axis synchronously regulates apoptosis and ferroptosis in pancreatic cancer cells. Redox Biol 38, 101807
33271455   Curated Info

2

Mun GI, Choi E, Lee Y, Lee YS (2020) Decreased expression of FBXW7 by ERK1/2 activation in drug-resistant cancer cells confers transcriptional activation of MDR1 by suppression of ubiquitin degradation of HSF1. Cell Death Dis
32457290   Curated Info

3

Lan H, et al. (2019) LSD1 destabilizes FBXW7 and abrogates FBXW7 functions independent of its demethylase activity. Proc Natl Acad Sci U S A 116, 12311-12320
31152129   Curated Info

4

Ji S, et al. (2015) ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer. Cell Res 25, 561-73
25753158   Curated Info

5

Min SH, et al. (2012) Negative regulation of the stability and tumor suppressor function of fbw7 by the pin1 prolyl isomerase. Mol Cell 46, 771-83
22608923   Curated Info