Ser1158
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Home > Phosphorylation Site Page: > Ser1158  -  mGluR5 (mouse)

Site Information
LVALTPPsPFRDSVD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25581600

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'neuron, striatal'-brain ( 1 ) , 293 (epithelial) ( 1 ) , HEK293T (epithelial) ( 2 ) , neuron-dorsal root ganglia ( 2 )

Upstream Regulation
Regulatory protein:
BDNF (human) ( 1 ) , FRMPD4 (human) ( 2 )
Putative in vivo kinases:
ERK1 (mouse) ( 2 ) , ERK2 (human) ( 2 )
Kinases, in vitro:
MAPKAPK2 (human) ( 1 )
Treatments:
cocaine ( 1 ) , SKF38393 ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on mGluR5:
molecular association, regulation ( 1 , 2 ) , protein conformation ( 1 )
Induce interaction with:
HOMER1 (human) ( 1 , 2 ) , PIN1 (human) ( 1 )

References 

1

Park JM, et al. (2013) A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. Cell 154, 637-50
23911326   Curated Info

2

Hu JH, et al. (2012) Preso1 dynamically regulates group I metabotropic glutamate receptors. Nat Neurosci 15, 836-44
22561452   Curated Info