Thr257
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Home > Phosphorylation Site Page: > Thr257  -  PINK1 (human)

Site Information
AGEYGAVtYRKSkRG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25544600

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 4 ) , mass spectrometry ( 2 , 4 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 4 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:
'blood, serum' ( 2 ) , 'neuron, hippocampal'-brain ( 3 ) , 293 (epithelial) ( 4 ) , cerebrospinal fluid ( 2 )

Upstream Regulation
Putative in vivo kinases:
PINK1 (human) ( 2 , 3 , 4 )
Kinases, in vitro:
PINK1 (human) ( 1 , 3 )
Treatments:
CCCP ( 4 )

Downstream Regulation
Effects of modification on PINK1:
intracellular localization ( 3 )
Effects of modification on biological processes:
apoptosis, inhibited ( 3 ) , autophagy, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Parkinson's disease ( 2 )

References 

1

Ponia SS, et al. (2021) Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues. Cell Rep 37, 109888
34706234   Curated Info

2

Geldenhuys WJ, Abdelmagid SM, Gallegos PJ, Safadi FF (2014) Parkinson's disease biomarker: a patent evaluation of WO2013153386. Expert Opin Ther Pat 24, 947-51
24962176   Curated Info

3

Hertz NT, et al. (2013) A Neo-Substrate that Amplifies Catalytic Activity of Parkinson's-Disease-Related Kinase PINK1. Cell 154, 737-47
23953109   Curated Info

4

Kondapalli C, et al. (2012) PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65. Open Biol 2, 120080
22724072   Curated Info

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