Thr211
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Home > Phosphorylation Site Page: > Thr211  -  p53 (human)

Site Information
EYLDDrNtFrHsVVV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25535400

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , breast cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
AurB (human) ( 1 )
Kinases, in vitro:
AurB (human) ( 1 )
Treatments:
AZD1152 ( 1 )

Downstream Regulation
Effects of modification on p53:
protein degradation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , cell cycle regulation ( 1 ) , transcription, inhibited ( 1 )

References 

1

Gully CP, et al. (2012) Aurora B kinase phosphorylates and instigates degradation of p53. Proc Natl Acad Sci U S A 109, E1513-22
22611192   Curated Info