Ser138
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Home > Phosphorylation Site Page: > Ser138  -  PIN1 (human)

Site Information
QkPFEDAsFALrTGE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25519816

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 3 ) , mass spectrometry (in vitro) ( 4 ) , mutation of modification site ( 1 , 2 , 4 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 4 )
Disease tissue studied:
breast cancer ( 4 ) , luminal A breast cancer ( 3 ) , breast cancer, triple negative ( 3 ) , liver cancer ( 2 ) , cholangiocellular carcinoma ( 2 ) , lung cancer ( 2 ) , small-cell lung cancer ( 2 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
MLK3 (human) ( 1 , 4 )
Kinases, in vitro:
MLK3 (human) ( 4 )
Treatments:
CEP1347 ( 1 )

Downstream Regulation
Effects of modification on PIN1:
intracellular localization ( 4 )
Effects of modification on biological processes:
cell cycle regulation ( 4 ) , transcription, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 4 ) , pancreatic ductal adenocarcinoma ( 1 )

References 

1

Viswakarma N, et al. (2021) Mixed Lineage Kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development. Cancer Lett 515, 1-13
34052323   Curated Info

2

Lepore A, et al. (2021) Phosphorylation and stabilization of PIN1 by JNK promote intrahepatic cholangiocarcinoma growth. Hepatology
34048060   Curated Info

3

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

4

Rangasamy V, et al. (2012) Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function. Proc Natl Acad Sci U S A 109, 8149-54
22566623   Curated Info