Lys21
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Home > Sumoylation Site Page: > Lys21  -  IkB-alpha (human)

Site Information
EGPRDGLkkERLLDD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 2535907

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
RWDD3 (human) ( 2 )

Downstream Regulation
Effects of modification on IkB-alpha:
protein stabilization ( 2 )
Effects of modification on biological processes:
transcription, inhibited ( 2 )

References 

1

Culver C, et al. (2010) Mechanism of Hypoxia-Induced NF-{kappa}B. Mol Cell Biol 30, 4901-21
20696840   Curated Info

2

Carbia-Nagashima A, et al. (2007) RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell 131, 309-23
17956732   Curated Info

3

Devalaraja MN, Wang DZ, Ballard DW, Richmond A (1999) Elevated constitutive IkappaB kinase activity and IkappaB-alpha phosphorylation in Hs294T melanoma cells lead to increased basal MGSA/GRO-alpha transcription. Cancer Res 59, 1372-7
10096573   Curated Info

4

Desterro JM, Rodriguez MS, Hay RT (1998) SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation. Mol Cell 2, 233-9
9734360   Curated Info