Ser314

Site Information
GtGsEAsstRRGGsL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 25299233

In vivo Characterization
Methods used to characterize site in vivo:	[32P] bio-synthetic labeling ( 4 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 2 , 5 ) , mutation of modification site ( 1 , 4 ) , western blotting ( 1 )
Disease tissue studied:	leukemia ( 1 ) , lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:	BaF3 ('B lymphocyte, precursor') ( 1 ) , CHO (fibroblast) ( 4 ) , CHO-K1 (fibroblast) ( 1 ) , HeLa (cervical) ( 1 ) , HL60 (myeloid) ( 1 ) , lung ( 2 ) , RBL-2H3 (basophil) ( 1 )

Downstream Regulation
Effects of modification on LTB4R:	phosphorylation ( 1 ) , receptor internalization, induced ( 4 )
Effects of modification on biological processes:	signaling pathway regulation ( 1 )

References
1	Nakanishi Y, et al. (2018) Stepwise phosphorylation of leukotriene B receptor 1 defines cellular responses to leukotriene B. Sci Signal 11 30131369 Curated Info
2	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
3	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
4	Aratake Y, et al. (2012) Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization. FASEB J 26, 4068-78 22707565 Curated Info
5	Gu T (2007) CST Curation Set: 2236; Year: 2007; Biosample/Treatment: cell line, RSK2-3/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info