Thr486

Site Information
GKTRVTItGLLPKTK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 2526946

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 )
Disease tissue studied:	cervical cancer ( 2 ) , cervical adenocarcinoma ( 2 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 1 ) , acute megakaryoblastic leukemia (M7) ( 1 ) , acute monoblastic leukemia (M5a) or acute monocytic leukemia (M5b) ( 1 ) , acute myeloblastic leukemia, with granulocytic maturation (M2) ( 1 )
Relevant cell line - cell type - tissue:	AML-193 (monocyte) ( 1 ) , CMK (megakaryoblast) ( 1 ) , HEL (erythroid) ( 1 ) , HeLa (cervical) ( 3 ) , HeLa S3 (cervical) ( 2 ) , Kasumi-1 (myeloid) ( 1 ) , KG-1 (myeloid) ( 1 ) , MV4-11 (macrophage) ( 1 ) , P31/FUJ (erythroid) ( 1 )

Upstream Regulation
Treatments:	nocodazole ( 2 )

References
1	Casado P, et al. (2013) Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors. Genome Biol 14, R37 23628362 Curated Info
2	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
3	Imami K, et al. (2008) Automated Phosphoproteome Analysis for Cultured Cancer Cells by Two-Dimensional NanoLC-MS Using a Calcined Titania/C18 Biphasic Column. Anal Sci 24, 161-6 18187866 Curated Info