Ser711
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser711  -  NFkB-p100 (human)

Site Information
PLPsPPTsDsDsDsE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25234803

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , multiple myeloma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 2 )

Downstream Regulation
Effects of modification on NFkB-p100:
protein degradation ( 1 , 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
FBXW7 (human) ( 2 )

References 

1

Busino L, et al. (2012) Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat Cell Biol 14, 375-85
22388891   Curated Info

2

Arabi A, et al. (2012) Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. Nat Commun 3, 976
22864569   Curated Info