Ser42
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Home > Phosphorylation Site Page: > Ser42  -  BMAL1 (mouse)

Site Information
CNRKRKGsATDYQLD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 25230400

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'neuron, hippocampal, CA1 pyramidal' ( 1 ) , 3T3-L1 (fibroblast) ( 2 ) , adipocyte ( 2 ) , adipose tissue ( 2 ) , brain ( 1 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Putative in vivo kinases:
p70S6K (human) ( 2 )
Treatments:
cLTP ( 1 ) , fasting ( 2 ) , high-fat diet ( 2 ) , rapamycin ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on BMAL1:
intracellular localization ( 1 ) , methylation ( 2 ) , molecular association, regulation ( 2 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
neural plasticity ( 1 ) , transcription, inhibited ( 2 )
Inhibit interaction with:
DNA ( 2 )

References 

1

Barone I, et al. (2023) Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity. Sci Adv 9, eadj1010
37878694   Curated Info

2

Yi SA, et al. (2022) S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2. Exp Mol Med
35338256   Curated Info