Tyr73

Site Information
QkLLEsDyFrYYKVN SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 457114

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 )
Disease tissue studied:	lung cancer ( 1 , 3 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) [FGFR1 (human), transfection, ZNF198-FGFR1 fusion protein] ( 2 ) , NCI-H1650 (pulmonary) ( 3 ) , PC9 (pulmonary) ( 1 ) , PC9-IR (pulmonary) ( 1 )

Upstream Regulation
Regulatory protein:	FGFR1 (human) ( 2 )

References
1	Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622 25814448 Curated Info
2	Kasyapa C, et al. (2009) Phosphorylation of the SSBP2 and ABL proteins by the ZNF198-FGFR1 fusion kinase seen in atypical myeloproliferative disorders as revealed by phosphopeptide-specific MS. Proteomics 9, 3979-88 19658100 Curated Info
3	Moritz A (2004) CST Curation Set: 623; Year: 2004; Biosample1/Treatment/Isotope: cell line, NCI-H1650/EGF/L, Biosample2/Treatment/Isotope: cell line, NCI-H1650/EGF/Iressa/H; Disease: non-small cell lung cancer; SILAC: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991 Curated Info